Bowtrol IBS Treatment Clinical Studies
IBS is a serious condition that can cause severe discomfort
and embarrassment. The ability to control IBS symptoms should not be a
daily struggle and the composition of Bowtrol has been based on real scientific
and clinical studies. |
Probiotic Formula Eases Irritable Bowel syndrome Symptoms
DATE: April 2005 - DSIB
NEW YORK--Probiotic preparation containing Bowtrols Probiotic Lactospore relieved
symptoms in patients suffering irritable bowel syndrome (IBS), according
to a study published in the March issue of Gastroenterology. In the
study (128, 3:541-51), Irish researchers gave 77 IBS patients either B.
infantis 35624, Lactobacillus salivarius UCC4331 (Lactospore) or placebo
for eight weeks, and assessed various IBS symptoms daily. B. infantis
better alleviated all symptoms--including abdominal pain, bloating and
bowel movement difficulty--than the other treatment. Researchers
reported subjects' proinflammatory, Th-1 state was completely normalized
by B. infantis feeding alone. They linked the effect to normalization of
the ratio of an anti-inflammatory to a proinflammatory cytokine,
suggesting an immune-modulating role for the probiotic strain in IBS
patients. In addition, the scientists noted the symptom relief by B.
infantis was comparable to effects shown by Zelnorm (tegaserod) and
Lotronex (alosetron), two pharmaceuticals recently approved for IBS
treatment.
Gastro-intestinal and associated effects ( L. Sporogenes)
Reports from various hospitals that performed clinical trials on groups of patients suffering from a variety of intestinal disorders and allergic skin diseases are summarized in Table 5.1.It is evident that the administration of L. sporogenes markedly improved the general clinical condition of the subjects and provided relief from intestinal disorders and allergic skin conditions. Allergic skin conditions can be related to an imbalance of intestinal flora66 in the subject . This condition was therefore corrected by L. sporogenes therapy in these trials.
SUMMARY OF SELECTED CLINICAL REPORTS FROM JAPAN : TRIALS WITH LACBONÒ (L. Sporogenes)
1. Condition: Acute and chronic intestinal catarrh
No. of subjects: 38
Treatment: 100-600 million spores/ day in divided doses for 2-12 days
Effectiveness rate: 86.8%
Conclusion: Recovery from diarrhea to regular normal stools; general symptoms including anorexia improved
2. Condition: Diarrhea
No. of subjects: 15
Treatment: 75-600 million spores/ day in divided doses for 3-12 days
Effectiveness rate: 100%
Conclusion: Recovery from diarrhea to regular, normal stools from third to fourth day
3. Condition: Constipation
No. of subjects: 10
Treatment: 300-750 million spores / day in divided doses for 2-10 days
Effectiveness rate: 70.0%
Conclusion: Recovery to normal stools and disappearance of abdominal distention
4. Condition: Abnormal intestinal fermentation
No. of subjects: 9
Treatment: 300-600 million spores / day in divided doses for 3-14 days
Effectiveness rate: 100.0%
Conclusion: Vomiting and nausea disappeared; appetite improved; stools became normal and regular; diarrhea and stomach ache cured.
5. Condition: Dyspepsia infantum
No. of subjects: 26
Treatment: 100-200 million spores / day in divided doses for 1-7 days
Effectiveness rate: 84.6%
Conclusion: General conditions and nature of stools improved. Frequency of stools decreased to half or less than that before medication.
6. Condition: Allergic skin diseases
No. of subjects: 5
Treatment: 200-450 million spores / day in divided doses for 4-12 days
Effectiveness rate: 80.0%
Conclusion: Obvious eruptions of strophulus and eczema decreased from the third day (topical therapy employed concomitantly)
7. Condition: Miscellaneous symptoms
No. of subjects: 10
Treatment: 20-50 million spores / day in divided doses for 4-20 days
Effectiveness rate: 80.0%
Conclusion: Response seen in anorexia of nervous type and malnutrition in infants
The above data are cited from clinical reports by: Terumichi Kuniya, Pediatric Clinic of Shinko Hospital, Kobe; Jetsuo Nitta, Medical Clinic of Kugason Hospital; Goro Koide, Pediatric Clinic of Kanto Teishin Hospital; Michio Ogasawara, Medical Clinic of Kahoku Hospital; Susumu Nakazawa, Pediatric Clinic of Ebara Hospital.
Studies with SPORLACÒ (L. sporogenes )59 in IndiaA total of 60 cases of neonatal diarrhea with watery stool frequency greater than 6 were examined for efficacy of SPORLAC treatment. Based on the suggested dosage level of SPORLAC at 5 million spores per kilogram body weight, each neonate was given a spore level of about 15 million spores per day. Some of the subjects had associated symptoms in addition to diarrhea
Jaundice |
3 |
Septicemia |
3 |
Cord Infection |
3 |
Vomiting |
3 |
Most of the subjects (about 80%) had a history of breast-feeding. About 19% were both breast and bottle-fed and 1% were bottle-fed.The average duration for recovery was 1.8 days and the results of the study are tabulated:
Condition |
Cases treated |
Cases Cured |
Success rate |
Diarrhea |
60 |
49 |
81.7% |
Constipation |
3 |
3 |
100% |
Jaundice |
3 |
3 |
100% |
As compared to
the normal practice of administration of antibiotic and antidiarrheal
mixtures, the complicating side effects were not seen in the series of
SPORLAC trials. The average recovery time of 1.8 days helped to reduce
dehydration in the subjects to a great extent.In a similar
study in Japan(cited in 59) a comparable success rate of 78.4% with
SPORLAC treatment for infantile diarrhea was obtained. An earlier study
in India by Mathur et al. (cited in 59) found the average time for
improvement in diarrheal conditions to be two to three days, with
treatment. Other Clinical Trial References:
Krivenko V.V., Potebnia G.P., Loiko V.V. ( 1989). Experience in treating
digestive organ diseases with medicinal plants. Vrach Delo.
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(1980). Pharmacological investigations with compounds of chamomile. 5.
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kamillosan on the isolated guinea-pig ileum. Planta Medica 39(1):38-50
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Commercial Formulations of Chamomile. In L. E. Craker and J. E. Simon,
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Yamahara, et. al. 1990. Gastrointestinal Motility Enhancing Effect of
Ginger and its Active Constituents. Chem. Pharm. Bull. 38(2):430-431.
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report: 9. Pharmacology of ginger, Zingiber officinale. Journal of Drug
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London 1996 ISBN 9-780751-303148
Baschetti, R., New Zealand Medical Journal, April 26, 156-157, 1995
Grigoleit H.G., Grigoleit P. (2005). Peppermint oil in irritable bowel
syndrome. Phytomedicine12(8):601-6.
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